Mammalian Ste20-like kinase 1 (MST1) is a component of the “Hippo” signaling pathway, and “has been implicated in regulating the cell cycle, apoptosis and cellular responses to oxidative stress.” Choi, J., et al., Plos One 4(11):e8011, 1 (2009). MST1-deficient mice reportedly display an accumulation of mature lymphocytes in the thymus and a decrease of lymphocytes in the blood and peripheral lymphoid tissues. Dong, Y., et al., J. Immunology 183(6):3865-3872, 3865 (2009). See also, Katagiri, K., et al., Nat Immunol. (9):919-28 (2006); Ling, P., et al., Cell Signal. 20(7):1237-47 (2008). MST1 is also known as serine/threonine kinase 4 (STK4) and kinase responsive to stress 2 (KRS2).